Yes, there are. When creating products with Printful’s push generator, integrations like Etsy require that all selected colors are available in all sizes. This means that if you selected one or more discontinued variants, the product won’t push to your store.
To make sure your products successfully push to your store, unselect all the discontinued variants when creating a product with Printful’s push generator. In the screenshot above, for example, you can either remove the yellow color from your store, or remove the sizes from all colors.